gender difference in cisplatin-induced nephrotoxicity in a rat model
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Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model
BACKGROUND Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), ni...
متن کاملgender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female
background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...
متن کاملHydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat
Hydrogen Sulfide (H2S) prevents and treats a variety of disorders via its cytoprotective effects. However, the effects of H2S on rats with cisplatin (CP) nephrotoxicity are unclear. The aim was to study the effects of H2S on rats with CP nephrotoxicity. Thirty male Sprague-Dawley rats were divided into three groups: control group, nephrotoxic group received sing...
متن کاملEffect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
متن کاملThe protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model
BACKGROUND Cisplatin (CP) as a potential drug for solid tumors produces nephrotoxicity and disturbs endothelial function. CP induced nephrotoxicity may be gender related. Nitric oxide plays a pivotal role in endothelial function and L-arginine as endogenous NO donor promotes endothelial function. The role of L-arginine in CP induced nephrotoxicity model and its gender related was investigated i...
متن کاملPretreatment with Darbepoetin Attenuates Renal Injury in a Rat Model of Cisplatin-Induced Nephrotoxicity
BACKGROUND/AIMS Darbepoetin alpha (DPO) exhibits comparable renoprotective effects to erythropoietin (EPO) in several animal models of acute renal injury. We examined whether DPO also attenuated renal injury in a rat model of cisplatin nephrotoxicity. METHODS Male Sprague-Dawley rats were divided into four groups: untreated, DPO-treated, cisplatin-injected, and DPO-treated cisplatin-injected....
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عنوان ژورنال:
nephro-urology monthlyجلد ۷، شماره ۲، صفحات ۰-۰
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